Linkage analysis of 5 novel van der Woude syndrome kindreds to 1q32-q41 markers further supports locus homogeneity of the disease trait.

van der Woude syndrome (vWS, MIM 119300) is a rare autosomal dominant clefting condition with cardinal features of mucous cysts (lower-lip pits) and clefts to the lip and/or palate.
The vWS gene has been assigned to a locus in 1q32-q41 by linkage analysis and physical mapping.
We have investigated 5 novel vWS families through probands attended for cleft lip and/or palate repair at the Department of Maxillofacial Surgery of Hopital Trousseau, Paris, in order to tentatively refine the genetic map of the vWS region in 1q32-q41 and possibly identify unlinked pedigrees.
Linkage analysis was carried out to 6 microsatellite markers (D1S249, D1S425, D1S491, D1S205, D1S414, D1S425), yielding a maximum cumulative LOD score of Z = 3. 27 at theta = 0. 00 for D1S245. The innermost four markers were found to be tightly linked to one another, with no evidence for recombination.
Our results support linkage of vWS within a region of tightly linked markers and do not favour locus heterogeneity of the disease trait.

